| Characteristic | Description |
|---|---|
| Chemical Name | Silag6CB47ra |
| Available Dosages | 10 mg, 20 mg, 50 mg |
| Formulation | Tablet |
| Administration Route | Oral |
| Explore More | |
Pharmacokinetics of Silag6CB47ra
Silag6CB47ra absorption occurs swiftly in the gastrointestinal tract. Peak plasma concentrations are achieved within 30 to 120 minutes post-administration. Bioavailability hovers around 40%, influenced by food intake. Distribution is extensive, with significant protein binding of approximately 96%. Silag6CB47ra undergoes hepatic metabolism predominantly through the cytochrome P450 system, particularly CYP3A4. Metabolites excreted via urine and feces. Half-life extends from 3 to 5 hours, making it suitable for once-daily dosing. Its pharmacokinetic profile ensures prolonged therapeutic effects.
Dosage Information for Effective Use
Prescribed doses range from 10 mg to 50 mg. Initiate therapy at the lowest dose to assess tolerance. Adjustments may be necessary based on clinical response and individual factors. Avoid exceeding the 50 mg maximum to mitigate adverse effects. Administer Silag6CB47ra with water, preferably on an empty stomach. Ensure consistent dosing intervals to maintain optimal plasma levels. Patients with renal or hepatic impairments require dosage adjustments. Regular monitoring is recommended for these groups.
Indications for Silag6CB47ra Use
Silag6CB47ra is indicated for the treatment of specific conditions. Primarily, it addresses erectile dysfunction by enhancing blood flow. The drug is effective in various severities, offering reliable improvement in erectile function. Additionally, Silag6CB47ra finds use in certain cases of pulmonary arterial hypertension, leveraging its vasodilatory properties. Further indications may include off-label applications, assessed on a case-by-case basis. Clinicians should ensure indications align with current guidelines and clinical evidence.
Cautions with Other Medicines
Interactions with concurrent medications necessitate caution. Nitrates combined with Silag6CB47ra pose a significant risk of hypotension. CYP3A4 inhibitors may alter the drug’s metabolism, necessitating dosage adjustments. Caution is advised when co-administering antihypertensives. Patients should report all medications, including over-the-counter drugs. Comprehensive interaction checks minimize adverse outcomes. For more information, visit the National Center for Biotechnology Information.
Toxicity Considerations
Silag6CB47ra toxicity primarily manifests with overdose. Symptoms include severe hypotension, visual disturbances, and prolonged erection. Immediate medical attention is required for priapism lasting over 4 hours. Hepatotoxicity, though rare, warrants regular liver function tests. Educate patients on recognizing overdose signs. Avoid alcohol and grapefruit juice, which can exacerbate side effects. Safety margins are narrow; adhere to prescribed limits to prevent toxicity.
Silag6CB47ra offers therapeutic benefits for well-defined indications. Adherence to dosage guidelines and interaction precautions enhances its safety profile. Always consult healthcare professionals for personalized advice.
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